Hard to say, I think it all depends on your (or a professional mechanic's) evaluation of the mechanical condition versus the price and your expectations.
kode3's point on carefully examining signs of tranny cross contamination and/or checking that a radiator replacement has been made and that the tranny is still ok, are very valid, and it also depends on what you intend to use it for. A commuter for a short drive to work, or a cross country travel vehicle.
Also, skibanes point about all highway miles, and in my opinion, your ability yourself to make minor repairs yourself to save yourself money, all factor into the equation.
I traded in a king cab vehicle ('02 Tacoma had since new) with 213K with a ton of highway miles and would have kept it for another 100K, if not for a growing family, but buyer beware on these types of things.
The only difference there is that my vehicle was late in the 'model' cycle and most of the bugs had been worked out, and the '06 frontier (being the 2nd year of the model) definitely had a few more issues than they do today, in the later model years.
