2wd or 4wd?
Like TO stated, if your pinion angle isn't straight with driveshaft, it will cause extra stress on the U-joints. If it is the rear U-joints, then you can use a pinion shim to change slightly rotate your rear axle to help fix the angle.
If it is the front, then idk since the diff is pretty much locked in place and when you lift it, it is the CVs that get fubared, not the U-joints.
Like TO stated, if your pinion angle isn't straight with driveshaft, it will cause extra stress on the U-joints. If it is the rear U-joints, then you can use a pinion shim to change slightly rotate your rear axle to help fix the angle.
If it is the front, then idk since the diff is pretty much locked in place and when you lift it, it is the CVs that get fubared, not the U-joints.