I put E-load rated 285/75/16's on my truck not long ago & the ride is much stiffer than it was with my stock size tires. Truth be told I do have to run them at 45psi or I get 12-14mpg if I go any lower. Let me tell ya, the ride isn't bad buuut I definitely feel more of the road through my backside than I did before.
I got really lucky with the way I have my truck setup & didn't have to do any trimming to the fenders or front air-damn at all after I bought my tires. However, I have to watch how fast I go over bumps &/or through rough areas while Im turning or I'll rub pretty good when the suspension is compressed.
Personally, I wouldn't go with the setup you're talking about at all unless you plan on lifting the truck 5"+. Then, with the right wheel & tire combo it would look pretty good. But, it is not my truck so knock yourself out! :smile: